Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis

Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis.

BACKGROUND Iron overload has been implicated in the pathogenesis of ischemic cardiovascular events. However, the effects of iron excess on vascular function and the thrombotic response to vascular injury are not well understood. METHODS AND RESULTS We examined the effects of chronic iron dextran administration (15 mg over 6 weeks) on thrombosis, systemic and vascular oxidative stress, and end...

Resveratrol increases vascular oxidative stress resistance.

Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. However, the mechanisms by which resveratrol exerts its vasculoprotective effects are not completely understood. Because oxidative stress and endothelial cell injury play a critical role in vascular aging and atherogenesis, we evaluated whether resveratrol in...

Iron Therapy and Oxidative Stress

Iron, Oxidative Stress and Health

Iron is an element of crucial importance to living cells. It has incompletely filled ‘d’ orbitals and exists in a range of oxidation states, the most common being ferrous [Fe II (d6)] and ferric [Fe III(d5)] forms. By virtue of this unique electrochemical property, iron is an ideal redox active cofactor for many biological processes and fundamental biochemical activities in all cells. It can as...

Chronic L-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition.

Hyperoxaluric kidneys show an impaired diuretic response to acute infusion of L-arginine. In this study, we examined the chronic effect of l-arginine supplementation on CaOx crystal formation in hyperoxaluric rat kidneys. Eight groups were tested: control (received drinking water), L group (received L-arginine, 0.6%), LN group [received NG-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg)], L + ...